CAS 698387-09-6 CAS 191732-72-6 GMP Manufacturer Raw Powder Chemical CAS 53123-88-9 Rapamycin CAS 417716-92-8

• CAS No.: 53123-88-9
• Formula: C51h79no13
• EINECS: 610-965-5
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: CAS 53123-88-9
• Colour: White
• Assay: 99%+
• Product Name: Rapamycin
• Storage: Cool and Dry
• Molecular Weight: 914.19
• Grade: Pharmaceutical Grade
• Application: Sineptina
• Package: Bottle.Box, Barrel
• Other Item: CAS 979-32-8 Estradiol Valerate CAS 4956-37-0
• Another Item: Algestone Acetophenide 24356-94-3/Acetylsalicylic
• One Item: CAS 906673-24-3
• Other Name: Crisaborole
• Others: Pantoprazole CAS 102625-70-7
• Another Name: Pantoprazole Sodium CAS 138786-67-1
• Addition: CAS 877399-52-5
• Brand: Pramlintide Acetate CAS 196078-30-5
• Transport Package: Glass Bottle, Plastic Bottle, Foil Bag, Carton
• Specification: Packaging can be customized
• Trademark: KANAL
• Origin: China
• Production Capacity: 8000kg/Month

Product Description

Product Name	Rapamycin
CAS No.	53123-88-9
Molecular Formula	C51H79NO13
Molecular Weight	914.19
EINECS No.	610-965-5
Appearance	White Powder
Brand Name	KANAL
Assay	99%+
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

Description:

Rapamycine is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production.

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

Function:
It is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2).

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

1.Progestins
1	Progesterone	57-83-0	USP42;EP9.0
2	Medroxyprogesterone Acetate	71-58-9	USP42;EP9.0
3	Megestrol Acetate	595-33-5	USP42
4	Altrenogest	850-52-2	In-house
5	Mifepristone	84371-65-3	CP2010
6	Medroxyprogesterone Base	520-85-4	In-house
7	Megestrol	3562-63-8	In-house,99%
8	17a-Hydroxyprogesterone caproate	630-56-8	USP42
9	Allylestrenol	432-60-0	In-house
2.Estrogens
1	Estrone	53-16-7	USP42
2	β-estradiol	50-28-2	USP42
3	Estriol	50-27-1	USP42,EP8.0
4	Estradiol Cypionate	313-06-4	USP42
5	Estradiol Valerate	979-32-8	USP42
6	Estradiol Benzoate	50-50-0	USP42,EP9.0
7	Estradiol Enanthate	4956-37-0	In-house
8	Estradiol Benzoate Butyrate	63042-18-2	In-house
9	Estradiol Dipropionate	113-38-2	In-house
10	2-Methoxyestradiol	362-07-2	In-house
11	β-Estradiol 17-acetate	1743-60-8	In-house
3.Intermediates
1	17a-hydroxyprogesterone	68-96-2	In-house
2	17a-hydroxyprogesterone Acetate	302-23-8	In-house
3	17-Hydroxy-6-Methylenepregn-4-Ene-3	32634-95-0	In-house
4	Pregnenolone	145-13-1	In-house
5	Pregnenolone Acetate	1778-02-5	In-house
7	6-Dehydroprogesterone	1162-56-7	In-house
10	6-Ketoprogesterone	2243-08-5	In-house
12	Dihydroproscar	98319-24-5	In-house
13	/	166896-74-8	In-house
18	acetate	853-23-6	In-house
22	Estradiene Dione-3-Keta	5571-36-8	In-house
4.Anti-Cancer Drug
2	Finasteride	98319-26-7	USP39