CAS No.: | 79217-60-0 |
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Formula: | C62h111n11o12 |
EINECS: | 1312995-182-4 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Refined |
Customization: |
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Product Name: | Cyclosporin A |
CAS: | 59865-13-3 |
MF: | C62H111N11O12 |
MW: | 1202.61 |
EINECS: | 611-907-1 |
Assay | 99%+ |
Appearance | White Powder |
Function:
1.An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
2.prothrombogenic agent
3.Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.
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