Description:
Bisacodyl is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Bisacodyl is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movemen Bisacodyl is a stimulant laxative. It stimulates the muscles in the wall of the small intestine and colon to generate a bowel movement. It also alters water and electrolyte levels inintestines, increasing the level of fluids which also produce a laxative-like effect.
Application:
It is a safe and effective drug for the treatment of constipation.
1.stomach cramps
2.faintness
3.stomach discomfort
Function:
Properties: In common with other stimulant laxatives, bisacodyl (which is of a related structure to phenolphthalein) stimulates accumulation of water and electrolytes in the colonic lumen and enhances intestinal motility. It may stimulate sodium/potassium-ATPase which may account for a portion of its laxative activity. It may also increase the synthesis of prostaglandins and cyclic-AMP, and this may contribute to increased secretion of water and electrolytes. Bisacodyl is rapidly converted by intestinal and bacterial enzymes to its desacetyl metabolite. As much as 5% of an oral dose is absorbed and excreted in the urine as the glucuronide. This inactive metabolite is also excreted in the bile and may be hydrolyzed to active drug in the colon.
| ITEM |
SPECIFICATION |
RESULT |
| Physical |
Appearance |
White powder |
Complies |
| CAS Number |
603-50-9 |
603-50-9 |
| Molecular formula |
C22H19NO4 |
C22H19NO4 |
| Molecular weight |
361.39 |
361.39 |
| EINECS Number |
210-044-4 |
210-044-4 |
| Identification |
IR-spectrum and HPLC retention
time comply with that of the reference
standard, calcium positive |
Complies |
Specific Rotation
(C=1.5%in water,25ºC) |
+38.0~+42.00 |
+39.10 |
| Calcium(Anhydrous basis) |
7.0%-8.5% |
8.1% |
| Sulfate |
≤0.015% |
complies |
| Chloride |
≤0.021% |
Conforms |
| Water (K-F) |
≤17.0% |
12.7% |
| Chemical |
Heavy metals (Pb) |
≤10ppm |
complies |
| (As2O3) |
≤1ppm |
complies |
| D-5-Methylfolate |
NMT 1.0% |
complies |
| Assay |
Assay (HPLC) |
98.0%~103.0% |
98.2% |
| Microorganism |
Total plate count |
≤1000cuf/g |
complies |
| Mold & Yeasts |
≤100cuf/g |
complies |
| Salmonella |
Negative |
complies |
| E. Coil |
Negative |
complies |
| Else |
Storage condition |
Store in sealed containers at cool & dry place.
protect from light,moisture and pest infestation. |
| Shelf life |
Two years when properly stored |
Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.
Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.
An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.
1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.
2.We can provide you with ten thousands of products of different levels.
3. We offer convenient one-station purchasing service.
(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.
Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.
The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.
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